Acute cardiac effects of neuregulin-1/ErbB signalling
نویسندگان
چکیده
منابع مشابه
Acute cardiac effects of neuregulin-1/ErbB signalling.
Neuregulin1 (Nrg1) is a member of the epidermal growth factor family. Its biological effects are mediated by the ErbB family of receptor tyrosine kinases (ErbB2, ErbB3, and ErbB4). Nrg1/ErbB signalling is an essential paracrine mediator of cell–cell interactions that are indispensable for cardiac development but also play a crucial role in the adult heart. In the foetal heart, Nrg1 is produced ...
متن کاملAntipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia.
Evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (NRG1) and its ErbB4 receptor plays in the pathophysiology of schizophrenia. This article aims to review current evidence regarding the effects of antipsychotic treatment on NRG1-ErbB4 signalling. NRG1 and ErbB4 knockout mice display abnormal behaviours relevant to certain featur...
متن کاملSignalling between microvascular endothelium and cardiomyocytes through neuregulin.
Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature ...
متن کاملEvaluating Protective Effects of Silymarin on Liver and Cardiac Side Effects of Chemotherapy Drugs in Childhood Acute Lymphoblastic Leukemia
Background: The protective effects of silymarin on liver and heart have been investigated and identified by many researchers. This study evaluates the protective effects of this substance on hepatotoxicity and cardiotoxcity of chemotherapy drugs in leukemic children. Materials and Methods: In this study, 71 children, aging 2-14 years old, going through the maintenance phase of acute lymphoblas...
متن کاملNeuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 0008-6363
DOI: 10.1093/cvr/cvq316